polysorbate 80 (ps80  (Merck & Co)

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I(q)v. q plot of 0.2 mg/mL (▲), 1.0 mg/mL (●) and 2.0 mg/mL (■) PS80 solutions in D2O at T=22∘C with core-shell ellipsoid model fits, where fit parameters are detailed in Table S3 of the supplementary materials. The presented error bars denoting one standard deviation are often smaller than the plot symbols.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot for low q of buffered 1.0 mg/mL PS80 and 3.15 mg/ mL m-cresol solution in D2O at T=22 °C, where solution age progresses from red to violet, as indicated by the arrow, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I(q)v. q plot comparing 1.0 mg/mL PS80 solutions aged for 2 days with and without 3.15 mg/mL m-cresol in D2O at T=22°C, including the core-shell ellipsoid model fit. The colored regions correspond to the general ranges for the low (q<0.007Å−1), mid (0.007Å−10.02Å−1) regions, where the plateau at q>0.1Å−1 is the background scattering. The presented error bars denoting one standard deviation are smaller than the plot symbols.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O compared with scattering intensity for solution of 1.0 mg/mL PS80 without m-cresol at T=(a)4 °C, (b) 22 °C and (c) 37 °C, where solution age progresses from red to violet, as indicated by the arrows, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Scattering intensity curves of (a) unbuffered (t/aT≈5.4) and (b) citrate buffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O showing same aggregate growth mechanism at T=4 °C, 22 °C and 37 °C and the times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot of buffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O compared with scattering intensity for solution of 1.0 mg/mL PS80 without m-cresol at T=(a)4 °C, (b) 22 °C and (c) 37 °C, where buffered solution age progresses from red to violet, as indicated by the arrows, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Rg(Å)v. t (h) a) plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C and (b) time-shifted master curve at T=4 °C (aT=10.6), 22 °C (aT=1) and 37 °C (aT=0.267) along with power-law fit, Rg=154Å⋅(t/aT)0.349, df=2.865.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques:

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I0(cm−1)v. t (h) a) plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22°C and 37°C and (b) time-shifted master curve at T=4 °C (aT=21.1), 22°C (aT=1) and 37°C (aT) with power-law fit. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Porod plot of buffered (open) and unbuffered (filled) 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C showing decrease in surface area with time. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Q∗(cm−1Å−3)v. t (h) unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C. Presented error bars denote one standard deviation.

Article Snippet: Materials Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I(q)v. q plot of 0.2 mg/mL (▲), 1.0 mg/mL (●) and 2.0 mg/mL (■) PS80 solutions in D2O at T=22∘C with core-shell ellipsoid model fits, where fit parameters are detailed in Table S3 of the supplementary materials. The presented error bars denoting one standard deviation are often smaller than the plot symbols.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot for low q of buffered 1.0 mg/mL PS80 and 3.15 mg/ mL m-cresol solution in D2O at T=22 °C, where solution age progresses from red to violet, as indicated by the arrow, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I(q)v. q plot comparing 1.0 mg/mL PS80 solutions aged for 2 days with and without 3.15 mg/mL m-cresol in D2O at T=22°C, including the core-shell ellipsoid model fit. The colored regions correspond to the general ranges for the low (q<0.007Å−1), mid (0.007Å−10.02Å−1) regions, where the plateau at q>0.1Å−1 is the background scattering. The presented error bars denoting one standard deviation are smaller than the plot symbols.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O compared with scattering intensity for solution of 1.0 mg/mL PS80 without m-cresol at T=(a)4 °C, (b) 22 °C and (c) 37 °C, where solution age progresses from red to violet, as indicated by the arrows, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Scattering intensity curves of (a) unbuffered (t/aT≈5.4) and (b) citrate buffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O showing same aggregate growth mechanism at T=4 °C, 22 °C and 37 °C and the times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Time-resolved I(q)v. q plot of buffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O compared with scattering intensity for solution of 1.0 mg/mL PS80 without m-cresol at T=(a)4 °C, (b) 22 °C and (c) 37 °C, where buffered solution age progresses from red to violet, as indicated by the arrows, and times are reported in hh:mm. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Rg(Å)v. t (h) a) plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C and (b) time-shifted master curve at T=4 °C (aT=10.6), 22 °C (aT=1) and 37 °C (aT=0.267) along with power-law fit, Rg=154Å⋅(t/aT)0.349, df=2.865.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques:

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: I0(cm−1)v. t (h) a) plot of unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22°C and 37°C and (b) time-shifted master curve at T=4 °C (aT=21.1), 22°C (aT=1) and 37°C (aT) with power-law fit. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Porod plot of buffered (open) and unbuffered (filled) 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C showing decrease in surface area with time. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation

Journal: Journal of pharmaceutical sciences

Article Title: Preservative Induced Polysorbate 80 Micelle Aggregation

doi: 10.1016/j.xphs.2020.12.030

Figure Lengend Snippet: Q∗(cm−1Å−3)v. t (h) unbuffered 1.0 mg/mL PS80 and 3.15 mg/mL m-cresol solution in D2O at T=4 °C, 22 °C and 37 °C. Presented error bars denote one standard deviation.

Article Snippet: Polysorbate 80 (PS80) and 99% m-cresol were obtained from Sigma-Aldrich (St. Louis, MO).

Techniques: Standard Deviation